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β-谷甾醇对脂质体抗氧化性及膜结构稳定性的影响

Effect of β-sitosterol on antioxidation and stability of liposomes

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【作者】 贺然刘国琴李琳

【Author】 HE Ran1,LIU Guoqin1,2,LI Lin1,2(1.School of Food Science and Technology,Henan University of Technology,Zhengzhou 450001,China; 2.College of Light Industry and Food Science,South China University of Technology, Guangzhou 510640,China)

【机构】 河南工业大学粮油食品学院华南理工大学轻工与食品学院

【摘要】 以旋转蒸发-超声法制备脂质体,比较了以β-谷甾醇为助膜材料的脂质体(PC/Sito脂质体)、以胆固醇为助膜材料的脂质体(PC/Chol脂质体)和不加助膜材料的脂质体(PC脂质体)在抵抗超声作用、AAPH(2,2-偶氮二(2-甲基丙基咪)二盐酸盐)引发的氧化作用、紫外线引发的氧化作用过程中的区别。结果表明:相比PC脂质体,PC/Sito脂质体和PC/Chol脂质体具有明显抵抗超声作用和推迟由AAPH引发的脂质体氧化反应发生的作用,并能有效维持脂质体在超声和氧化过程中脂质体的稳定性;在维持脂质体稳定性的效果上,β-谷甾醇优于胆固醇;在抵抗紫外线引发的脂质体氧化的过程中,3种脂质体未表现出明显区别。

【Abstract】 Liposomes were prepared by conventional rotary evaporation-sonication method from lecithin with β-sitosterol or cholsterol or nothing,forming three different liposome systems,such as PC/Sito liposomes,PC/Chol liposomes and PC liposomes.The effects of ultrasonic,AAPH and ultraviolet radiation on each liposomes were evaluated.The results indicated that the PC/Sito liposomes and PC/Chol liposomes could stand against ultrasonic and delay oxidation induced by AAPH compared with PC liposomes.Furthermore,β-sitosterol and cholesterol could maintain the stability of the liposomes through ultrasonic and oxidation induced by AAPH,and β-sitosterol was more effective.There was no obviously difference among the three systems in the oxidation induced by ultraviolet radiation.

【基金】 国家自然科学基金项目(31130042,20976036);国家科技支撑计划项目(2012BAD37B00);广东省科技计划项目(2010B031700014,2010B050600003)
  • 【文献出处】 中国油脂 ,China Oils and Fats , 编辑部邮箱 ,2012年09期
  • 【分类号】TQ641
  • 【被引频次】11
  • 【下载频次】344
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