【摘要】 以旋转蒸发-超声法制备脂质体,比较了以β-谷甾醇为助膜材料的脂质体(PC/Sito脂质体)、以胆固醇为助膜材料的脂质体(PC/Chol脂质体)和不加助膜材料的脂质体(PC脂质体)在抵抗超声作用、AAPH(2,2-偶氮二(2-甲基丙基咪)二盐酸盐)引发的氧化作用、紫外线引发的氧化作用过程中的区别。结果表明:相比PC脂质体,PC/Sito脂质体和PC/Chol脂质体具有明显抵抗超声作用和推迟由AAPH引发的脂质体氧化反应发生的作用,并能有效维持脂质体在超声和氧化过程中脂质体的稳定性;在维持脂质体稳定性的效果上,β-谷甾醇优于胆固醇;在抵抗紫外线引发的脂质体氧化的过程中,3种脂质体未表现出明显区别。更多还原

【Abstract】 Liposomes were prepared by conventional rotary evaporation-sonication method from lecithin with β-sitosterol or cholsterol or nothing,forming three different liposome systems,such as PC/Sito liposomes,PC/Chol liposomes and PC liposomes.The effects of ultrasonic,AAPH and ultraviolet radiation on each liposomes were evaluated.The results indicated that the PC/Sito liposomes and PC/Chol liposomes could stand against ultrasonic and delay oxidation induced by AAPH compared with PC liposomes.Furthermore,β-sitosterol and cholesterol could maintain the stability of the liposomes through ultrasonic and oxidation induced by AAPH,and β-sitosterol was more effective.There was no obviously difference among the three systems in the oxidation induced by ultraviolet radiation.更多还原