【摘要】 目的:探讨血清血管内皮生长因子与C反应蛋白在早期强直性脊柱炎患者发病中的作用及表达水平。方法:采用免疫学方法,检测53例早期强直性脊柱炎患者和39名健康对照者血清中血管内皮生长因子及C反应蛋白水平,进行统计学分析。结果:早期强直性脊柱炎患者组中血清血管内皮生长因子、C反应蛋白水平均显著高于健康对照组(P<0.05),表明血管内皮生长因子、C反应蛋白是早期强直性脊柱炎患者发病过程中的重要炎症指标。结论:血管内皮生长因子是与强直性脊柱炎发病相关的细胞因子,直接或间接参与早期强直性脊柱炎炎症的发生、血管增生及关节软骨破坏等病理过程,联合C反应蛋白检测可能更好的反映了参与疾病活动性的指标,可以有效的应用于强直性脊柱炎的早期活动期实验室指标辅助诊断的检测方法。更多还原

【Abstract】 Objective:To explore the expression and effect of VEGF,CRP in early ankylosing spondylitis(AS) patients.Methods:VEGF and CRP were measured and analized in 53 patients with early AS and another 39 cases in healthy control group.Results:The serum VEGF、CRP level in the AS patients was significantly higher than that in the control group(P<0.05),it show that the level of VEGF and CRP was important indicator of inflammation in the early AS patients.Conclusion:VEGF is a cytokine associated with AS disease,directly or indirectly involved in the early AS inflammation and vascular proliferation and pathological processes of articular cartilage destruction,it may better reflect the disease activity together with CRP testing,and it can be effectively used as laboratory markers for early diagnosis of active detection.更多还原