【摘要】 目的探讨ABO血型不合对清髓异基因造血干细胞移植(allo-HSCT)造血重建的影响。方法选取2007年4月至2011年12月在温州医学院附属第一医院接受ABO血型不合清髓allo-HSCT21例受者和同期接受ABO血型相合allo-HSCT20例受者,观察两组红细胞系、粒细胞系、血小板重建情况。结果与ABO血型相合组比较,血型不合组红细胞系重建时间明显延长(中位时间分别为20d和10.5d,P<0.05),粒细胞和血小板植活时间差异均无统计学意义(均P>0.05)。血型主要不合、次要不合、主次要均不合3个亚组红细胞系重建时间差异无统计学意义(P>0.05)。Cox比例风险模型多因素分析结果显示,移植物中CD34+细胞数量是影响ABO血型不合组红细胞系重建时间的因素(P<0.05)。结论 ABO血型不合受者可以进行清髓allo-HSCT,CD34+细胞数量是影响ABO血型不合造血重建的主要因素。更多还原

【Abstract】 Objective To investigate the effect of ABO-incompatible myeloablative allogeneic hematopoietic stem cell transplantation(allo-HSCT) on hematopoietic engraftment.Methods The clinical data of 21patients who received ABO-incompatible allo-HSCT in the First Affiliate Hospital of Wenzhou Medical College from April 2007 to December 2011 were analyzed.Twenty patients matched who received ABO-compatible allo-HSCT in the same period served as controls.Blood routine examination was dynamically observed and analyzed between the 2 groups.Results The recovery of erythrocytic series reconstitution was prolonged to 20 d in ABO-incompatible patients as compared to 10.5 d in ABO-compatible patients(P < 0.05).No difference in platelet and the neutrophil reconstitution was noted between the ABO-compatible and ABO-incompatible patients(P > 0.05).Time of red blood cells engraftment was not different among major,minor,and bidirectional ABOincompatible groups(P > 0.05).Cox proportional hazard model analysis demonstrated that number of CD34 + cells were correlated with erythrocytic series in ABO-incompatible patients(P < 0.05).Conclusions Myeloablative allo-HSCT is safe in ABO-incompatible patients if there is any indication.The number of CD34 + cells are correlated with erythrocytic series.更多还原