【摘要】 目的通过对高尿酸血症与冠心病及危险因素的横断面研究,分析高尿酸血症与冠心病及危险因素的相关性。方法入选太原市中心医院心内科符合标准患者150例,依据尿酸水平分为高尿酸血症组(80例)及非高尿酸血症组(70例)。记录年龄、性别、身高、体重、腰围、臀围、血压及血生化指标等基本资料,通过横断面研究高尿酸血症与冠心病及危险因素的关系。结果高尿酸血症组与非高尿酸血症组比较,在吸烟年限、收缩压(SBP)、舒张压(DBP)、腰围、腰臀比、体重指数(BMI)、三酰甘油、总胆固醇、空腹血糖等均有统计学意义(P<0.05)。高尿酸与冠心病间存在相关性。针对高尿酸血症危险因素空腹血糖(FBG)、低密度脂蛋白胆固醇(LDL-C)、BMI以及代谢综合征(MS)四者进行多元Logistic回归分析,并校正年龄、性别、吸烟、饮酒后分析表明,MS(校正前OR=1.110,校正后OR=1.111,P<0.001)及FBG(校正前OR=2.586,校正后OR=2.685,P<0.001)是高尿酸血症的独立危险因素,而LDL-C(校正前OR=0.638,校正后OR=0.642,P<0.05)则是高尿酸血症的保护因素。BMI的Logistic回归分析无统计学意义(校正前OR=0.795,校正后OR=0.757)。结论高尿酸血症与冠心病存在一定的协同作用;在高尿酸血症的危险因素中MS、FBG是高尿酸血症的独立危险因素,LDL-C是高尿酸血症的保护因素。更多还原

【Abstract】 Objective To analyze the relationship between hyperuricemia,coronary heart disease and its risk factors.Methods One hundreds and fifty patients(pts) were divided into high uric acid group(n=80) and non-high uric acid group(n=70).The age,sex,height,weight,waist circumference(WC),hip circumference(BP),blood pressure,blood glucose,creatinine,uric acid,total cholesterol(TC),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C) and high density lipoprotein-cholesterol(HDL-C) and other basic information were recorded and analyzed by cross-sectional study.Results There were significantly difference in years of smoking,systolic BP(SBP),diastolic BP(DBP),WC,waist to hip(WHR),body mass index(BMI),TG,TC,fasting blood glucose(FBG),and creatinine in two groups(P<0.05).Adjusting for age,sex,smoking,and alcohol consumption,FBG,LDL-C,BMI and metabolic syndrome(MS) were analyzed by multivariate logistic regression analysis and showed MS[odds ratio(OR)=1.110,adjusted OR=1.111,P<0.001],FBG(OR=2.586,adjusted OR=2.685,P<0.001),and higher serum uric acid were independent risk factor.LDL-C(OR=0.638,adjusted OR=0.642,P<0.05) was a protective factor for hyperuricemia.There was no relation between hyperuricemia and BMI(OR=0.795,adjusted OR=0.757).Conclusion There is certain relation between coronary heart disease and hyperuricemia.MS and FBG is an independent risk factor of hyperuricemia,and LDL-C is a protective factor of hyperuricemia.更多还原