【摘要】 目的:评价葛根素注射液治疗急性脑梗死的治疗效应和安全性。方法:检索PubMed、CNKI、维普中文科技期刊全文数据库及万方数据库,纳入葛根素治疗急性脑梗死的随机对照临床试验研究文献,采用Jadad评分标准评价纳入研究项目的质量,用RevMan5.0统计软件进行分析。结果:15篇文献共纳入受试者1603例。采用随机效应模型分析,葛根素治疗急性脑梗死与对照组比较总有效率具有显著差异[RR=0.16,95%CI(0.11,0.21),Z=6.04,P<0.00001]。采用固定效应模型分析,葛根素治疗急性脑梗死的神经功能缺损评分值与对照组比较具有显著差异[OR=-3.85,95%CI(-4.24,-3.46),Z=19.33,P<0.00001]。结论:葛根素注射液治疗急性脑梗死疗效优于对照组治疗。但由于纳入的研究少、质量低,故尚不能得出完全肯定的结论,需高质量、大样本、多中心的随机研究进一步验证。更多还原

【Abstract】 Objective : To evaluate the efficacy and safety of puerarin injection in patients on acute cerebral infarction(ACI).Methods: The PubMed,CNKI,VIP and Wan Fang databases were searched to retrieve randomized controlled trials assessing the efficacy and safety of puerarin injection versus control therapy in the treatment of ACI.The quality of the included studies was evaluated with the Jadad score.Statistical analysis was carried out by RevMan 5.0.Results: 15 studies involving a total of 1603 patients were included.The results of meta analysis showed significant differences between puerarin injection versus control therapy of total effective rate,neural function defect scale.Conclusion: Puerarin injection is effective in the treatment of ACI.The conclusion need to high quality,large sample and multicenter randomized controlled trials to confirm because of the research too less and the quality low.更多还原