【摘要】 目的分析2010年-2011年中山地区对重大出生缺陷采取的监控和干预措施在降低唐氏综合征出生率方面的实际效果。方法 2010年1月1日始中山市对户籍人口实施免费产前筛查唐氏综合征,并进行监控和干预措施,通过2008年-2011年中山市出生缺陷监测网监测唐氏综合征儿数据,比较唐氏综合征出生率的差异。结果实施重大出生缺陷监控和干预措施后,唐氏综合征的产前诊断率显著提高,唐氏综合征出生率2010年-2011年(1.63-0.64/万)较2008年-2009年(3.5-3.78/万)有明显下降(P=0.001)。结论 2010年-2011年中山市对重大出生缺陷采取监控和干预措施在降低唐氏综合征出生率方面起到很好的效果。更多还原

【Abstract】 Objective: To analysize the effect of the surveillance and intervention of severe birth defects on decreasing the incidence of live birth with Down′s syndrome in Zhongshan,2010-2011.Methods: Prenatal screening of Down′s syndrome has been free in residents since January 1,2010.The Surveillance and Intervention were carried out at the same time.Data of the surveillance were analyzed,2008-2011,comparing the difference of the incidences.Results: After the surveillance and intervention,the rate of prenatal diagnosis of Down′s syndrome increased significantly.The rate of live births with Down′s syndrome decreased in 2010-2011(1.63-0.64/ten thousand)compared with 2008 and 2009(3.5-3.78/ten thousand).Conclusion: The Surveillance and intervention of severe birth defects on were effective on decreasing the incidence of live birth with Down′s syndrome in Zhongshan.更多还原