【摘要】 目的探讨TGF-α基因TaqⅠ位点多态性与中国人群非综合征性唇腭裂的相关性。方法以非综合征性唇腭裂患者与对照组TGF-α基因TaqⅠ位点等位基因及基因型分布的OR值为效应指标,通过检索中国学术文献总库、维普、万方以及MEDLINE,PubMed,EMBASE等数据库中的相关文献,使用STATA10.0对各研究进行异质性检验和效应值合并,进行发表偏倚和敏感性分析。结果最终纳入11篇病例对照(病例亲本)研究,其中病例组1177例,对照组1293例。以等位基因C1以及基因型C1C1为参照,提示在TGF-α基因TaqⅠ位点中携带等位基因C2与非综合征性唇腭裂发病显著相关,携带C1C2或C2C2基因型的个体发生NSCL/P的风险增加(OR=2.00,95%CI:1.63～2.46)。结论在中国人群中,TGF-α基因TaqⅠ位点携带C1C2或C2C2基因型可能是非综合征性唇腭裂发病的危险因素。更多还原

【Abstract】 Objective: To explore whether transforming growth factor α Taq Ⅰpolymorphism is associated with NSCL/P susceptibility.Methods: Computerized literature searches of the CNKI,VIP,WanFang,PubMed,Embase and Medline database were conducted to identify all eligible articles.Study subjects were non-syndromic cleft lip with or without cleft palate patients.The pooled odds ratios with 95% confidence interval(CI) were calculated by fixed-effects model or random-effects model.STATA10.0 was used to do all analysis.Results: This meta-analysis included 1177 cases and 1293 controls from 11 published case-control studies.Taking allele C1 and genotype C1C1 as reference,the C1C2 or C2C2 genotype carriers had significantly higher risk of NSCL/P,OR=2.00(95%CI,1.63~2.46).No significant evidence of publication bias was present.Conclusion: This meta-analysis suggests that transforming growth factor α Taq Ⅰpolymorphism is associated with NSCL/P susceptibility in Chinese population,which C1C2 or C2C2 genotype carries an approximately two-fold increased risk of NSCL/P.更多还原