【摘要】 目的探讨胰岛素样生长因子-Ⅰ(IGF-Ⅰ)与胎儿生长受限(FGR)的相关性。方法采用放射免疫法和免疫放射法测定20例FGR孕妇(FGR组)和17例正常孕妇(对照组)的血清及新生儿脐血IGF-Ⅰ水平,并对其结果进行相关性研究。结果 FGR组孕妇血清IGF-Ⅰ(115.44±4.34)μg/L,低于对照组(121.92±10.51)μg/L(P<0.01),差异有统计学意义;FGR组脐血清IGF-Ⅰ(121.48±5.85)μg/L,低于正常组的(124.24±10.08)μg/L(P<0.01),差异有统计学意义;孕妇血清IGF-Ⅰ水平与新生儿出生体重无相关性(r=0.189,P>0.05)。新生儿脐血IGF-Ⅰ水平与新生儿出生体重呈正相关(r=0.575,P<0.05)。结论 IGF-Ⅰ可能在FGR的发病中有重要的作用,并可能为将来诊断和治疗FGR提供新的途径。更多还原

【Abstract】 Objective:To explore the relationship between the level of insulin-like growth factor-1(IGF-1) and the pathogenesis of fetal growth restriction.Methods:Immunoradioassay was used to measure the IGF-1 level of serum and cord blood in 20 pregnant women with FGR(FGR group) and 17 normal pregnant women(control group),and the results in both groups were analyzed.Results:The maternal serum IGF-1 in FGR group(115.44±4.34)μg/L was significantly lower than that in the control group(121.92±10.51)μg/L(P < 0.01).The umbilical serum IGF-1 in FGR group(121.48±5.85)μg/L was significantly lower than that in the control group(124.24±10.08)μg/L(P < 0.01).The maternal serum IGF-1 was not correlated with fetus birth weight(r=0.189,P>0.05).The umbilical serum IGF-1 had positive relationship with the neonatal weight(r=0.575,P<0.05).Conclusions:The change of IGF-1 level may play an important role in the pathogenesis of FGR,and merit clinical diagnosis and therapy of FGR.更多还原