【摘要】 目的以壳聚糖和海藻酸钠为基质材料,在此基础上加入纳米CdS(硫化镉)制备缓释性能优异的载药微球。该实验包裹的药物为卵磷脂,卵磷脂在发挥功效的同时兼作两性离子型表面活性剂,可望替代当前较多采用的非离子型表面活性剂司盘-80或吐温-80。方法以微球的包封率为制备工艺优化指标,利用复凝聚法,通过正交实验筛选微球的最佳制备工艺条件,同时在最佳工艺基础上加入CdS制备微球。结果最佳制备工艺:壳聚糖0.24 mg/ml,搅拌速度800 r/min,反应温度25℃,交联剂戊二醛用量2.0 ml,CdCl20.004 mol,Na2S 0.004 mol。结论用液体石蜡、卵磷脂、壳聚糖、海藻酸钠、戊二醛,不添加非离子型表面活性剂司盘-80或吐温-80,即可制备形态规整的微球;加入CdS纳米粒子的微球具有较好的缓释作用。更多还原

【Abstract】 [Objective]To prepare microspheres of supported lecithin using the chitosan and sodium alginate e as the matrix material,with the aid of nanoparticle CdS.Lecithin is not only used as the drug but also surfactant which can replace span-80 or tween-80 in tradition.[Methods]Complex coacervation was the method of preparation of microspheres.The ratio of encapsulation acting as the preparation optimization target,the best technology was screened with orthogonal design.Based on the condition of the best technology,the nanoparticle CdS was added to microspheres.[Results] The optimum condition was chitosan concentration 2.40 mg/ml,stirring speed 800 r/min,reaction temperature 25 ℃,crosslinking agent glutaric dialdehyde 2.0 ml,CdCl2 0.004 mol,Na2S 0.004 mol.[Conclusion]Using liquid paraffin,lecithin,chitosan,alginate,glutaric dialdehyde,microspheres can be prepared without span-80 or tween-80 in tradition.The chitosan lecithin microspheres of nano-CdS has good sustained properties.更多还原