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职业性锰接触对工人尿锌水平的影响

Effect of occupational manganese exposure on urinary zinc levels of workerss

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【作者】 谭玉凤吴南翔金锋楼建林陶核刘克澄宋杨

【Author】 TAN Yu-feng,WU Nan-xiang,JIN Feng,LOU Jian-lin,TAO He,LIU Ke-cheng,SONG Yang Zhejiang Academy of Medical Sciences,Hangzhou,310013,China

【机构】 浙江省医学科学院

【摘要】 目的预防工人职业性锰中毒,寻找锰中毒早期预警指标。方法对148名职业性锰接触工人和100名对照人员进行了尿锰、尿锌水平的检测。结果锰暴露组人群与对照组尿锰差异无统计学意义(t=0.195,P>0.05;尿锌暴露组显著低于对照组,分别为(2.08±0.48)和(3.21±0.64)μmol/L,差异有统计学意义(t=15.15,P<0.01);而尿锌浓度随尿锰浓度升高而降低,呈负相关(P<0.01)。结论过量锰可能影响人体内锌的正常代谢,尿锌浓度的检测对于锰中毒的早期诊断具有参考意义。

【Abstract】 [Objective]To prevent occupational manganese poisoning of workers,and look for early warning indicators of manganese poisoning.[Methods]Urine manganese and zinc levels detection was performed on 148 workers with occupational exposure and 100 controls.[Results] There was no significant difference of urine manganese level between manganese exposure group and the control group(t=0.195,P>0.05).Urine zinc level of zinc exposure group(2.08±0.48) μmol/L was significantly lower than that of control group(3.21±0.64) μmol/L(t=15.15,P<0.01).Urine zinc level decreased with increasing level of urine manganese,showing negative correlation(P<0.01).[Conclusion]Excessive manganese level can affect the normal metabolism of human body.Urinary zinc level detection has reference value in early diagnosis of manganese poisoning.

【基金】 浙江省科技条件建设项目(项目编号:2011F10016)
  • 【文献出处】 职业与健康 ,Occupation and Health , 编辑部邮箱 ,2012年16期
  • 【分类号】R131
  • 【被引频次】3
  • 【下载频次】61
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