【摘要】 目的探讨虎眼万年青对大鼠的致畸作用。方法用大鼠进行致畸胎试验,将动物分成5组:阴性对照组(蒸馏水)、虎眼万年青低剂量组(2.5 g/kg)、中剂量组(3.3 g/kg)、高剂量组(4.1 g/kg)和阳性对照组(维生素A),分别在妊娠的7～16 d灌胃给予。妊娠期间记录孕鼠体重,于妊娠第20天断头处死孕鼠,记录着床数、活胎数、死胎数和吸收胎数;检查胎鼠外观、内脏和骨骼,并称胎鼠体重,量体长。结果阳性对照组,活胎率为90.7%,与对照组(99.3%)比较明显降低(P<0.05);迟死胎率和吸收胎率分别为1.3%、7.9%,与对照组比较明显增高(P<0.05)。4.1、3.3、2.5 g/kg剂量组的孕鼠和胎鼠的各项毒效应观察指标与对照组相比,差异均无统计学意义(P>0.05)。结论在该实验剂量与条件下,虎眼万年青对孕鼠生长和胚胎发育无不良影响和致畸作用。更多还原

【Abstract】 [Objective] To study the teratogenicity of Ornithogalum caudatum Ait in Wistar rats.[Methods] Wistar rats were adopted to conduct the teratogenic test.The regnant rats were divided randomly into five groups,including negative control group(distilled water),low dose Ornithogalum caudatum Ait group(2.5 g/kg),middle dose group(3.3 g/kg),high dose group(4.1 g/kg) and positive control group(vitamin A).The agents were administered respectively by gavage during the 7th-16th day of pregnancy.The body weight of regnant rats was recorded during pregnancy.The rats were killed by decapitation on the 20th day of pregnancy.The number of embryo implantation,living fetuses,dead fetuses and absorbed fetuses was recorded.The appearance,internal organs and skeleton of fetal rats were tested.The body weight and length of fetal rats were also measured and examined.[Results] The rate of living fetuses in the positive control group(90.7%) was lower than that in the negative control group(99.3%) significantly(P<0.05).The rate of late dead fetuses and absorbed fetuses in the positive control group was 1.3% and 7.9% respectively,which were significantly higher than those in the negative control group(P<0.05).There was no significant difference in toxic effect indexes of regnant rats and fetal rats between low dose group(2.5 g/kg),middle dose group(3.3 g/kg),high dose group(4.1 g/kg) and the control group(P>0.05).[Conclusion] Under the doses and conditions of this study,Ornithogalum caudatum Ait has no harmful effect and teratogenicity on growth and development of regnant rats and fetal rats.更多还原