CC chemokine receptor 4(CCR4) is one of the G-protein-coupled receptors with a characteristic seven-transmembrane structure.CCR4 plays an important role in the formation and development of autoimmune diseases,asthma,atopic dermatitis,etc.,which has caused more and more attention of scholars.CCR4 can be used as a novel choice for treating such diseases.In this paper,the advances in the research on small molecule CCR4 antagonists are reviewed.
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