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吡贝地尔缓释片致晕厥1例

One case of piribedil-induced syncope

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【作者】 胡云珍袁敏卢晓阳

【Author】 HU Yun-zhen1,YUAN Min2,LU Xiao-yang1(1 Department of Pharmacy,2 Department of Neurology,The First Affiliated Hospital, College of Medicine,Zhejiang University,Hangzhou 310006,China)

【机构】 浙江大学医学院附属第一医院药剂科浙江大学医学院附属第一医院神经内科

【摘要】 1例65岁男性患者,因一氧化碳中毒后出现走路持物不稳、反应迟钝、记忆力下降入院。为了治疗患者一氧化碳中毒引起的帕金森综合征,医嘱给予吡贝地尔缓释片50 mg,qd。患者服药1.5 h后坐起出现晕厥,当时测血压111/62 mmHg,卧床休息并补液后好转,测血压142/71 mmHg。13 d后再次服用吡贝地尔缓释片50 mg,2 h后起床去做高压氧途中出现头晕、出冷汗,伴恶心,返回病房后测血压118/65 mmHg,卧床休息后好转,测血压150/75 mmHg。患者两次服用吡贝地尔缓释片后出现类似反应,有时间相关性,又有可重复性,考虑为该药引起的不良反应。

【Abstract】 A 65-years-old male patient was sent to the hospital for CO poisoning-caused ataxia,slow respondence and memory loss.In order to modify the Parkinson’s symptom,piribedil sustained-release tablet 50mg,qd,was taken.The patient appeared syncope with a blood pressure value of 111/62mmHg 1.5h after taking the drug,and recovered after fluid infusion and bed rest and blood pressure returned to 142/71mmHg.He took piribedil sustained-release tablet again 13d later.2h after taking the drug,he felt dizziness,cold sweats and nausea on his way to hyperbaric oxygen therapy.The blood pressure was 118/65mmHg when he back,and also recovered to 150/75mmHg after bed rest.The patient took piribedil sustained-release tablet twice with similar adverse reactions.This was correlated with time and repeatable,therefore,it should be considered as the drug-caused adverse reactions.

  • 【文献出处】 中国新药杂志 ,Chinese Journal of New Drugs , 编辑部邮箱 ,2012年04期
  • 【分类号】R595.3
  • 【被引频次】3
  • 【下载频次】124
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