【摘要】 目的探讨鼻咽癌放射治疗对甲状腺的影响。方法收集43例接受放射治疗的鼻咽癌患者资料,观察其甲状腺体积及激素水平变化,记录引起甲状腺损伤时的放疗剂量。结果患者放疗后甲状腺体积缩小,FT3及FT4水平降低,较放疗前具有统计学意义(P<0.05);随访发现FT3及FT4水平降低,于放疗后12个月开始具有统计学意义(P<0.05),后有所回升,TSH则持续升高,具有统计学意义(P<0.05);引起FT3及FT4水平变化的放疗剂量为4 500 cGy,引起TSH水平变化的放疗剂量为5 500 cGy。结论鼻咽癌患者放射治疗可对甲状腺造成损伤,放疗剂量阈值在4 500~5 500 cGy左右。更多还原

【Abstract】 【Objective】 Explore effects of radiation therapy for nasopharyngeal carcinoma towards thyroid gland.【Methods】 Collected 43 patients with nasopharyngeal carcinoma treated with radiation therapy,then observed changes of thyroid volume and hormone levels,recorded the radiotherapy dose starting bringing damages.【Results】 Volume of thyroid gland and levels of FT3 and FT4 decreased significantly after radiation therapy(P <0.05);levels of FT3 and FT4 decreased significantly when followed-up till 12 months after radiation therapy and then increased(P ≤0.05,level of TSH increased significantly after radiation therapy(P <0.05);The radiation dose caused damage to thyroid gland was 4500 cGy for FT3 and FT4,5500 cGy for TSH.【Conclusion】 Radiation therapy for nasopharyngeal carcinoma could damage thyroid gland,the threshold was around 4 500～5 500 cGy.更多还原