【摘要】 目的探讨相对脑血容量(relative cerebral blood volume,rCBV)变化和血管内皮生长因子(vascular endothelialgrowth factor,VEGF)表达对胶质母细胞瘤全切手术后辅助放射治疗病人的无进展生存期(PFS)和总生存期(OS)的预测作用。方法回顾性分析16例外科全切术后辅助放射治疗的胶质母细胞瘤病人的临床资料。在放射治疗前和放射治疗中(累计放射剂量为30 Gy)各进行1次灌注成像检查,计算rCBV值。免疫组化检测VEGF表达。采用Kaplan-Meier生存曲线分析PFS和OS。结果不同年龄、VEGF表达和rCBV变化的病人,其在PFS的差异具有统计学意义(均P<0.05)。仅有VEGF表达不同的病人在OS的差异具有统计学意义(P<0.05)。结论 VEGF表达和rCBV变化可以作为判定胶质母细胞瘤PFS的预测物。同时,VEGF表达可以作为判定胶质母细胞瘤OS的预测物。更多还原

【Abstract】 Objective To analyze the predictive effects of change of relative cerebral blood volume(rCBV) and expression of vascular endothelial growth factor(VEGF) on progression free survival(PFS) and overall survival(OS) in glioblastoma patients treated by total resection assisted with postoperative radiotherapy.Methods Clinical data of 16 glioblastoma patients treated by total resection assisted with postoperative radiotherapy were analyzed retrospectively.The dynamic susceptibility contrast-enhanced perfusion MR imaging was performed to calculate the rCBV before and during radiotherapy(the total radiation dose,30 Gy).The expression of VEGF was detected by immunohistochemistry.PFS and OS were analyzed by Kaplan-Meier survival curves.Results There were significant differences in PFS between patients with different ages,VEGF expressions and rCBV changes(all P < 0.05).There was obvious difference in OS between patients with different expressions of VEGF(P < 0.05).Conclusions VEGF expression and rCBV changes can be considered as the predictors of PFS,and VEGF expression can also be a predictor of OS in glioblastoma patients.更多还原