【摘要】 目的:探讨十二烷基苯磺酸钠(SDBS)对雄性小鼠生育力的影响。方法:分别将120只昆明种雌、雄性小鼠随机分为4组,每组30只。A组为与染毒SDBS两个月后的雄性小鼠交配的雌鼠;B组为与染毒SDBS两个月,停止染毒一个月后的雄鼠交配的雌鼠。A、B两组分别设对照组为a组、b组。对各组怀孕率、孕鼠平均产子数及其胎鼠情况进行比较分析。结果:与对照组相比,A、B两组的怀孕率、孕鼠平均产子数、孕鼠腹中死胎、畸胎与吸收胎比例明显降低,有显著性差异(P<0.05);A、B两组相比,小鼠怀孕率、孕鼠平均产子数、孕鼠腹中死胎、畸胎与吸收胎比例无显著性差异(P>0.05)。结论:十二烷基苯磺酸钠对雄性小鼠的生育力有显著影响,并且在停止染毒后的短时期内不能恢复。更多还原

【Abstract】 Objective:To determine the effects of sodium dodecyl benzene sulfonate(SDBS) on reproduction of male mice.Methods:Both 120 Kunming male mice and 120 female mice were randomly divided into four groups and the number of every group was 30.Group A was the female mice which were mated with the male mice gavaged by SDBS for two months;Group B was the female mice which were mated with the male mice gavaged by SDBS for two months and stopped for one month.Group a and group b were the control groups respectively.The pregnancy rates,the average birth number of pregnant rats and the fetal rats of these groups were studied.Results:The pregnancy rates,the average birth number of pregnant rats and the proportion of deaths,malformation and absorbed fetuses in pregnant rats was lower than the control groups,there was significant difference(P<0.05).However,there was no significant difference between group A and group B(P>0.05).Conclusion:Sodium dodecyl benzene sulfonate have an significant toxicity effect on the reproduction of male mice and they cannot restore after leaving off being gavaged for a short time.更多还原