【摘要】 目的:通过检测急性缺血性脑卒中患者血浆非对称二甲基精氨酸(ADMA)水平,探讨两者的关系,为临床早期诊断、治疗提供依据。方法:选择急性缺血性脑卒中患者(162例)为研究对象,未卒中患者(100例)作对照,血浆ADMA检测采用高效液相色谱法。结果:(1)急性缺血性脑卒中组血浆ADMA水平明显高于对照组,差别有统计学意义(t=1.438,P=0.000)。血浆ADMA浓度与急性缺血性脑卒中的风险成正相关(2)各型急性缺血性脑卒中血浆ADMA水平差别均无统计学意义(P>0.05)。结论:ADMA是急性缺血性脑卒中的危险标志物,测定ADMA水平有助于指导预防策略,为急性缺血性脑卒中的预防及临床治疗提供依据。更多还原

【Abstract】 Objective:To explore the relationship of acute ischemic stroke and asymmetric dimethylarginine through the concentration detection of ADMA in plasma of patients with acute ischemic stroke,so as to provide basis for early diagnosis and treatment in clinic.Methods: 162 patients with acute ischemic stroke were selected as research objects and 100 patients without stroke were control group,plasma ADMA detection was done by HPLC.Results: ADMA level in plasma of patients with acute ischemic stroke was obviously higher than that in control group,the difference had statistical significances(t=1.438,P=0.000).ADMA concentration in plasma and the risk of acute ischemic stroke showed positive correlation.The difference of ADMA level in various acute ischemic stroke patients had no statistical significances(P>0.05).Conclusion: ADMA was a risk marker of acute ischemic stroke,concentration determination of ADMA can contribute to guide prevention and control and provide basis for clinical treatment.更多还原