【摘要】 糖尿病,特别是2型糖尿病,已成为一个全球性的健康威胁。随着国内人民生活水平的提高,膳食结构和生活方式的改变导致了与糖脂代谢紊乱相关疾病的迅猛增加。其中,糖尿病人群已接近1亿,糖尿病前期人群大约2亿。糖尿病相关的合并症,如大血管病变、微血管病变和肿瘤已成为国内人群主要的致死和致残原因。我国糖尿病患者人数急剧增多的原因可能是遗传和环境因素综合作用的结果,涉及易感基因、表观遗传作用、糖脂代谢紊乱等众多因素。近年来,我国在糖尿病流行病学调查、遗传易感基因确定、膳食营养因子作用、胰岛素分泌调节、胰岛素敏感性调控、糖脂代谢紊乱机制、合并症发生机制和防治策略制定方面取得了长足进步。然而,糖尿病危害的消除还有赖于政府、社会、医药界及患者的共同努力。更多还原

【Abstract】 Diabetes mellitus,especially type 2 diabetes,has become a major health problem worldwide.Improved living standards have led to changes in the diet and lifestyle of the Chinese people,which has resulted in a dramatic increase in the incidence and prevalence of diabetes in China.It is estimated that there are 100 million people in China with diabetes and another 200 million people with prediabetes.Diabetes related diseases,such as macrovascular and microvascular complications and tumors,are considered to be leading causes of death and disability in China.The marked increase in the prevalence of diabetes in China may be attributed to a complex interaction between genetic and environmental factors,involving susceptible genes,epigenetic modification,and dysregulation of glucose and lipid metabolism.In recent years,China has made enormous progress in understanding diabetes epidemiology,determining susceptible genes,improving insulin secretion and sensitivity in patients,devising strategies to prevent and treat diabetes.However,successful prevention and treatment of diabetes will ultimately require the combined efforts of the government,society,the medical and pharmaceutical community,and patients themselves.更多还原