【摘要】 目的研究氯沙坦对维持性血液透析(MHD)患者左心室肥厚(LVH)的影响及其与炎症和氧化应激的关系。方法将伴有LVH的MHD患者随机分为氯沙坦组和安慰剂组,每位患者服用氯沙坦50-100mg/日或安慰剂6个月,二维超声心动图检测心脏并计算左心室重量指数(LVMI),同时检测患者血清超敏-C反应蛋白(hs-CRP)和丙二醛(MDA),分析左心室重量指数的变化与hs-CRP和MDA的关系。结果治疗后6个月,氯沙坦组左心室重量指数,血清hs-CRP,丙二醛(MDA)水平均降低,与治疗前比均有统计学意义(P<0.01),LVMI下降的数值与hs-CRP和MAD下降的数值均具有相关性(分别为r=0.805,r=0.778,P均<0.01);而安慰剂组以上指标与治疗前比无统计学意义(P>0.05)。结论氯沙坦可逆转MHD患者LVH,改善炎症及氧化应激状态,逆转LVH的作用与改善MHD患者炎症及氧化应激状态有关。更多还原

【Abstract】 Objective To study the effect of losartan on left ventricular hypertrophy(LVH) in patients with maintenance hemodialysis(MHD) and the relationship between effect of losartan and charge of inflammation and oxidative stress state.Methods MHD patients with LVH in our dialysis center were devived into losartan group and placebo group.Patients had taken losartan 50-100mg/d or placebo for 6 months.Left ventricular mass index(LVMI) were measured by echocardiography.hs-CRP and MDA level were measured at the baseline,3 month and 6 month.Results All measured markers were significantly changed after taking losartan for 6 month:LVMI(125.21±19.39 vs 140.16±22.13 g/m2,P<0.01),hs-CRP(3.79±1.73 VS 6.22±2.03mg/L,P<0.01).MDA(4.36±1.62 vs 5.45±1.87(mol/L,P<0.01).Descended numerus of LVMI possess correlation with charge of CRP and MAD(r=0.805,P<0.01;r=0.778,P<0.01;respectively.).However measured markers of placebo group is no statistics difference in experiment duration.Conclusion Losartan is a effective drug to reverse LVH though improving inflammation and oxidative stress state in MHD patients.更多还原