【摘要】 综述了模式识别受体(Pattern recognition receptors,PRRs)及其相关分子佐剂的研究进展。PRRs是一类表达于固有免疫细胞并可识别病原体相关分子模式的识别分子。PRRs主要包括Toll样受体、NOD样受体、RIG-Ⅰ样受体、清道夫受体、甘露糖受体和髓系细胞触发受体等。与PRRs直接相关的分子佐剂主要包括TLR激动剂、NLR激动剂、RIG-Ⅰ和MDA5激动剂及CD40和肿瘤坏死因子受体超家族(TNFRSF)激动剂等。更多还原

【Abstract】 In this paper,the developments of PRRs and its relevant molecular adjuvants were reviewed.PRRs were a kind of recognition molecules expressed on innate immune cells that can recognize pathogen-associated molecular patterns(PAMPs).PRRs mainly included Toll-like receptors(TLRs),NOD-like receptors(NLRs),RIG-Ⅰ like receptors(RLRs),scavenger receptors(SRs),mannose receptors(MRs) and triggering receptors expressed on myeloid cells(TREMs),etc.Molecular adjuvants directly related to PRRs mainly including TLR agonists,NLR agonists,RIG-I & MDA5 agonists and CD40 & tumor necrosis factor receptor of superfamily(TNFRSF) agonists,etc.更多还原