【摘要】 目的通过观察脑梗死患者血浆内皮细胞素(ET)、基质金属蛋白酶-9(MMP-9)水平的动态变化与梗死面积、神经损害的关系,从临床方面探讨二者在脑梗死发展过程中的作用。方法对70例脑梗死患者第三天和病后14d的血浆采用免疫分析法内皮细胞素、采用酶联免疫法测定基质金属蛋白酶-9,进行不同时程和同期神经功能缺损程度、脑梗死体积进行相关分析,并与30例正常人对照。结果 70例脑梗死患者第3天时血浆ET、MMP-9浓度为均显著高于对照组(P<0.05)。脑梗死患者血浆ET、MMP-9水平CTV≥10cm3、与CTV<10cm3比较(P<0.05)。不同程度神经功能受损患者血浆ET、MMP-9水平CSS>30与CSS≤30之间比较(P<0.05)。ET、MMP-9水平呈正相关,(r=0.428,P<0.001)。结论 ET、MMP-9参与脑梗死的病理过程,脑梗死急性期血浆ET、MMP-9水平可作为判断梗死面积大小、病情轻重及预后的客观指标。更多还原

【Abstract】 Objective The dynamic changes of ET,MMP-9 in patients with cerebral infarction and the relation of ET,MMP-9 leves to infarct size and intensity of neurological deficit,the ET,MMP-9 in plasma were detected to investigation the effect of ET,MMP-9 to the time course of in ischemic stroke.Methods By RIA,ET concentration in plasma and by ELISA,MMP-9 concentration in plasma were measured in 70 patients with acute cerebral infarction(ACI),on days 3 and 14 after onset and 30 control subjects.At the same time,canadian stroke scale(CSS) score and cerebral infarction volume(CTV) were also obtained and analyzed.Results Mean plasma ET,MMP-9 concentrations in 70 patients significantly elevated compared with control subjects on day 3,(P<0.05).Moreover Mean plasma ET,MMP-9 concentrations in patients with CTV≥10 cm3,CSS >30 were significantly higher than those with CTV<10 cm3,CSS≤30,(P<0.05).ET concentrations was significantly positively correlated with MMP-9 in plasma(r=0.428,P<0.001).Conclusion ET,MMP-9 are involved in the pathologic process of cerebral infarction.The concentrations of ET and MMP-9 may be helpful as an objective guide to judging the degree,size of infarction area and the recent prognosis in acute cerebral infarction.更多还原