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冬青注射液血管刺激性、溶血性及过敏性试验研究

Experimental studies of Maodongqing injection on vascular stimulation,haemocytolysis and anaphylaxis

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【作者】 张芳艳赵欣欣辛志伟

【Author】 ZHANG Fang-yan,ZHAO Xin-xin,XIN Zhi-wei.Department of Pharmacology,Pharmaceutical College of Chengdu Medical College,Chengdu,Sichuan 610083,China

【机构】 成都医学院药学院药理教研室重庆市食品药品检验所

【摘要】 目的评价毛冬青注射液的安全性,为临床用药提供实验依据。方法通过血管刺激性试验、体外溶血性试验、全身主动过敏性试验(ASA)和被动皮肤过敏试验(PCA),评价毛冬青注射液的安全性。结果毛冬青注射液无明显血管刺激性;无溶血和凝集反应;豚鼠全身主动过敏性试验与被动皮肤过敏试验均为阴性。结论在本次实验条件下,毛冬青注射液符合注射剂安全要求。

【Abstract】 Objective To valuate the safety of Maodongqing injection and provide evidence for clinical medication.Methods The safety of Maodongqing injection were observed through vascular stimulation test,hemolytic test,active systemic anaphylaxis(ASA) and passive cutaneous anaphylaxis(PCA).Results Maodongqing injection did not have obvious vascular irritative effects and hemo1ysis reaction.Of the active systemic anaphylaxis and passive cutaneous anaphylaxis were both negative.Conclusion The Results showed that Maodongqing injection should be safe under the experimental conditions,it was complianced with requirement of injection safety.

  • 【文献出处】 中国实用医药 ,China Practical Medicine , 编辑部邮箱 ,2012年23期
  • 【分类号】R285.5
  • 【被引频次】6
  • 【下载频次】307
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