【摘要】 目的检测冠心病(CHD)患者、血清淀粉样蛋白(SAA)及白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和超敏C-反应蛋白(hs-CRP)的变化,探讨其在CHD发病机制中的意义。方法检测22例急性心肌梗死(AMI)、25例不稳定性心绞痛(UA)、30例稳定性心绞痛(SA)、30例健康者血清SAA、IL-6、TNF-α和hs-CRP水平。结果 CHD患者血清SAA、IL-6、TNF-α和hs-CRP水平均较对照组高(P<0.01);并呈AMI>UA>SA的趋势(P<0.05和0.01),且在冠脉单支病变、双支病变、三支病变者逐渐增高(P<0.01);SAA与IL-6、TNF-α和hs-CRP水平显著相关(P<0.01)。结论 SAA、IL-6、TNF-α和hs-CRP可能参与了CHD的发病过程,可作为CHD病情观察的指标,以预防CHD急性冠脉事件的发生。更多还原

【Abstract】 Objective To detect the changes of serum amyloid A protein(SAA),interleukin-6(IL-6),tumor necrosis factorα(TNF-α)and hypersensitive C-reactive protein(hs-CRP) in patients with coronary heart disease(CHD),and investigate the significance in the pathogenesis of CHD.Methods We detected the levels of SAA,IL-6,TNF-α and hs-CRP in 22 patients with acute myocardial infarction(AMI),25patients with unstable angina(UA),30 patients with stable angina(SA) and 30 healthy volunteers.Results The levels of SAA,IL-6,TNF-α and hs-CRP were higher in patients with CHD than those in the healthy control group(P<0.01),and had a tendency of AMI>UA>SA(P<0.05 and 0.01).A significant correlation were found between SAA and IL-6,TNF-α and hs-CRP(P<0.01).Conclusion The levels of SAA,IL-6,TNF-α,hs-CRP which may be involved in CHD development and act as observational indices of patients condition,can prevent the acute coronary events in patients with CHD.更多还原