【摘要】 目的:观察丹红注射液对行经皮冠状动脉介入治疗(PCI)的急性冠脉综合征(ACS)患者心肌的保护作用。方法:采用前瞻性试验设计,将68例拟行PCI治疗的ACS患者按随机数字表法分为治疗组和对照组,两组各34例患者。均给予常规治疗,治疗组加用丹红注射液40 mL,同时纳入本院健康体检者40例作为健康组。观察所有被试PCI术前、术后即刻、治疗14 d的血浆内皮素-1(ET-1)、P选择素(CD62p)、高敏C反应蛋白(hs-CRP)、治疗7 d后ST段回落率。采用SAS 9.0统计学软件对数据进行统计学分析。结果:ACS患者术前的血浆ET-1,CD62p,hs-CRP均高于健康组,差异均有统计学意义(P<0.05),治疗组与对照组相比差异无统计学意义。治疗14 d后,两组患者ET-1,CD62p,hs-CRP水平均较治疗前下降,差异有统计学意义(P<0.05);治疗组与对照组相比,治疗组ET-1,CD62p,hs-CRP均低于对照组,差异有统计学意义(P<0.05)。治疗7 d后治疗组ST段回落率高于对照组,差异有统计学意义(P<0.05)。结论:丹红注射液可以抑制ASC患者PCI术后的炎症反应,保护内皮细胞,建议作为PCI术后保护心肌的治疗措施在临床推广。更多还原

【Abstract】 Objective:Explore the effects of Danhong injection on protect myocardium of acute coronary syndrome(ACS) patients after selective percutaneous coronary artery intervention(PCI).Method: Using a prospective design of experiments,the 68 patients of the intended line of PCI with ACS were randomly divided into treatment group and control group,each group is 34 patients.At the same time into the hospital health examination in 40 cases as health group.Observation the level of all patients of plasma endothelin-1(ET-1),P-selectin(CD62p),high enzyme C reactive protein(hs-CRP) and after treatment of 7 d ST segment resolution rate at PCI preoperatively,immediately after operation,treatment of 14 d.Using SPSS 9.0 statistical software for data statistics and analysis.Result: ACS patients preoperative plasma levels of ET-1,CD62p,hs-CRP were higher than the healthy group,The differences were statistically significant(P<0.05).The treatment group compared with the control group,the difference was not statistically significant 14 days after treatment,two groups of patients with ET-1,CD62p,hs-CRP levels were decreased compared with those before treatment,the difference was statistically significant(P<0.05);The treatment group compared with the control group,treatment group,ET-1,CD62p,hs-CRP were lower than the control group,the difference was statistically significant(P<0.05).After treatment of 7 d,the treatment group ST segment resolution higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion: Danhong injection can inhibit ASC in patients with PCI postoperative inflammatory reaction,protection of endothelial cells,is proposed as PCI postoperative myocardial protection measures in clinical treatment更多还原