【摘要】 目的:观察心脉隆胶囊(XMLJ)对高脂血症大鼠血脂及肝脂的治疗作用。方法:一次性ip维生素D 6×105U.kg-1,喂食高脂饲料4周建立大鼠高脂血症模型。建模后用不同剂量(450,300,150 mg.kg-1)的XMLJ ig治疗4周,测定大鼠血清血脂含量、过氧化损伤及内皮损伤程度,观察肝组织病理改变。结果:XMLJ各剂量均能降低总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、丙二醛(MDA)、内皮素-1(ET-1)、血栓素B2(TXB2)含量,升高高密度脂蛋白胆固醇(HDL-C)、一氧化氮(NO)、前列环素(PGI2)含量和超氧化物歧化酶(SOD)活力(P<0.05),肝组织损伤减轻。结论:XMLJ能调节高脂血症大鼠血脂水平,提高机体抗氧化损伤能力,改善血管内皮功能,减轻肝脏脂肪变性程度。更多还原

【Abstract】 Objective:To observe the effects of Xinmailong capsules(XMLJ) on the blood lipid and hepatic tissue in the rats with hyperlipidemia.Method: The hyperlipidemia model was established by injected intraperitoneally(ip) vitamin D 6×105 IU·kg-1 at once and given high fat forage for four weeks.Then modeling rats were treated with different doses of XMLJ(450,300,150 mg·kg-1),and four weeks later,the levels of blood lipid were measured,the degree of peroxide and endothelium injury were observed,including the hepatic tissue pathology.Result: The total cholesterol(TC),triglyeeride(TG),low density lipoprotein-cholesterol(LDL-C) and malondialdehyde(MDA),endothelin-1(ET-1),thromboxane B2(TXB2) at different dosages of XMLJ were significantly decreased,and the high density lipoprotein-cholesterol(HDL-C),nitric oxide(NO),prostacyclin(PGI2)with XMLJ were markedly increased,meanwhile,it could increase SOD activity,steatosis of hepatic tissue was significantly reduced.Conclusion: XMLJ could regulatedblood lipid level,improve antioxidation ability,enhance vascular endothelial function and relieve the liver steatosis.更多还原