【摘要】 目的:制备十一酸睾酮微乳,并以水溶性高分子材料为辅料制备外用微乳巴布剂。方法:选用肉豆蔻酸异丙酯(IPM)为油相,Cremophor EL为表面活性剂,Larbrasol为辅助表面活性剂,制备微乳。使用聚乙烯吡咯烷酮(K-90)、聚丙烯酸钠(NP-700)等为基质,制备巴布剂。对制备的巴布剂进行了质量考察,采用体外扩散池法测定了巴布剂中十一酸睾酮的透皮渗透率。结果:最终制备得到的微乳巴布剂中十一酸睾酮载药量400μg.cm-2,经皮渗透速率3.822μg.cm-2.h-1。结论:所选择的微乳处方黏度小、粒径细腻、质量稳定,制备得到的巴布剂具有良好的涂展性、保湿性,且黏着力适中。微乳巴布剂具有明显的控释效果。更多还原

【Abstract】 Objective:To prepare testosterone undecanoate(TU) microemulsion,and microemulsion cataplasm was prepared with water-soluble polymer materials as accessories.Method:Isopropyl myristate was chosen for oil phase,Cremophor EL was selected as surfactants,Larbrasol was used as auxiliary surfactants to prepare microemulsion.PVP K-90 and NP-700 were used as matrix to prepare cataplasm.Quality of prepared cataplasm was investigated,transdermal penetration of TU was determined by in vitro diffusion cell method.Result:TU loading ability of prepared microemulsion cataplasm was 400 μg·cm-2.Percutaneous penetration of TU was 3.822 μg·cm-2·h-1.Conclusion:This selected microemulsion prescription had low viscosity,fine particle and stable quality.TU microemulsion cataplasma had good extension,moisture,viscosity,and obviously drug control-release ability.更多还原