【摘要】 目的:观察刺蓝抗疲口服液对手术后疲劳综合征(POFS)大鼠模型的作用及其机制。方法:将60只SD大鼠随机分成空白组、假手术组、模型组、刺蓝抗疲口服液低、中、高剂量组(4.7,9.4,18.8 g.kg-1.d-1)。采用切除大鼠部分肝脏的方法建立POFS大鼠模型,以肛温、体力活动、血常规、白蛋白、转铁蛋白等为指标,观察ig给药7 d刺蓝抗疲口服液对POFS大鼠的影响。结果:刺蓝抗疲口服液中剂量组大鼠在悬挂实验中的抬头次数与抬头最高高度与模型组有显著差异(P<0.01),术后大鼠肛温的恢复与模型组有差异(P<0.01);高剂量组大鼠白蛋白、转铁蛋白明显提高(P<0.05)。结论:刺蓝抗疲口服液能缩短模型大鼠POFS持续时间,减轻POFS的程度。更多还原

【Abstract】 Objective:To observe the influence and the mechanism of Cilan Kangpi oral liquid on postoperative fatigue syndromes(POFS).Method:Sixty SD rats were randomly divided into six groups:normal control group,model group,sham operation group,low-dose Cilan Kangpi group(4.7 g·kg-1),middle-dose Cilan Kangpi group and high-dose Cilan Kangpi group.Using the resection of partial liver of rats to establish POFS model,anus temperature,physical activity,blood tests,albumin and transferrin were observed after Cilan Kangpi oral liquid was given for seven days.Result:Compared with model group,the frequency and height of rising head and in middle dose group in suspension experiment were obviously different(P<0.01),the recovery of anus temperature was different(P<0.01)after surgery;albumin and transferrin of high doses of rats were obviously improved(P<0.05).Conclusion:Cilan Kangpi oral liquid can shorten the duration and reduce the degree of POFS in model rats.更多还原