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TB-IGRA与TST检测菌培阳性肺结核患者比较

Diagnostic applications of TB-IGRA and TST in patients with culture-positive tuberculosis

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【作者】 张向东郑蓉蓉何水珍熊君辉葛胜祥张军牛建军

【Author】 ZHANG Xiang-dong,ZHENG Rong-rong,HE Shui-zhen, XIONG Jun-hui,GE Sheng-xiang,ZHANG Jun,NIU Jian-jun(Xiamen Center for Disease Control and Prevention,National Institute of Diagnostics and vaccine Development in infectious diseases,Xiamen university,Xiamen 361005,China)

【机构】 厦门市疾病预防控制中心厦门大学生命科学学院/国家传染病诊断试剂与疫苗工程技术研究中心

【摘要】 目的比较结核分枝杆菌γ-干扰素体外释放试验(TB-IGRA)与结核菌素皮肤试验(TST)在临床上用于检测MTB感染者的应用价值。方法 TB-IGRA与TST平行检测对147例菌培阳性肺结核患者,并分析年龄、性别和是否接种卡介苗对各自检测性能的影响。TST分别比较红肿硬块直径≥5mm(TST5)和≥15mm(TST15)者。结果 TB-IGRA和TST5的检出率分别为80.3%(118/147)和78.2%(115/147),均显著高于TST15的44.2%(65/147)。TB-IGRA在60岁以下年龄组的检出率显著高于60岁以上年龄组,TST15检出率随年龄变化趋势与TB-IGRA类似。是否接种卡介苗对TB-IGRA和TST15没有明显影响,而TST5在接种过卡介苗的患者中的阳性率显著高于未接种组。结论 TB-IGRA比TST有更高的检测灵敏度,可以作为判断结核分枝杆菌感染的手段之一。

【Abstract】 The aim was to evaluate the clinical value on detecting Mycobacterium tuberculosis(MTB) of interferon-gamma release assay(TB-IGRA) comparing with tuberculin skin test(TST).Total of 147 cases of culture-positive tuberculosis patients were parallelly detected with TB-IGRA and TST,and the influence on their performance of age,sex and BCG vaccination were analyzed.TST was evaluated with two different criteria,diameter of swelling lumps ≥ 5mm(TST5) and ≥ 15mm(TST15) respectively.Results indicated that the positive rates of TB-IGRA and TST5 were 80.3%(118/147) and 78.2%(115/147) respectively,and significantly higher than 44.2% of TST15(65/147).The positive rate of TB-IGRA in patients below 60-year-old was significantly higher than those above 60-year-old,and that was observed in the results of TST15.Vaccination of BCG had no influence on the preformation of TB-IGRA and TST15,but the positive rate of TST5 was significantly higher in vaccinated group than in non-vaccinated group.In conclusion,TB-IGRA has higher sensitivity than TST,and could be used as one of the means to detect the MTB infection.

【基金】 国家十一五科技重大专项资助项目(2008ZX10003-004);福建省自然科学基金(2009-51);厦科发计(2009-15);厦卫科教中医(2009-627)联合资助
  • 【文献出处】 中国人兽共患病学报 ,Chinese Journal of Zoonoses , 编辑部邮箱 ,2012年05期
  • 【分类号】R521
  • 【被引频次】20
  • 【下载频次】249
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