【摘要】 目的:筛选出最佳的右美沙芬(Dextromethorphan,DM)咀嚼胶制剂处方,制备制剂并进行质量评价。方法:采用正交设计优化咀嚼胶制剂,压片法制备DM咀嚼胶制剂。结果:正交设计优化后的DM咀嚼胶制剂最佳处方为:胶基、阿斯巴甜、薄荷脑和香精的用量分别为90%、3%、0.5%和0.2%。结论:DM咀嚼胶制剂制备工艺合理,质量符合要求。更多还原

【Abstract】 Objective:To select the best prescription for Dextromethorphan(DM) chewing gum preparation and to evaluate its quality.Methods: The DM chewing gum preparation was prepared by tablet press method;the formulation was optimized by orthogonal experiments.Results: The best prescription based on the results of orthogonal experiments was that the proportion of gum base,aspartame,menthol and essence was 90%,3%,0.5% and 0.2%,respectively.Conclusion: DM chewing gum preparation can be successfully formulated and its quality can be guaranteed.更多还原