【摘要】 目的:通过回顾性分析各种围产期危险因素对新生儿缺氧缺血性脑病(HIE)发生的可能影响,寻求预防HIE发生及改善其预后的方法。方法:对302例HIE患儿性别、胎龄、出生体重、临床表现、母亲孕期病史及分娩情况进行回顾性调查分析。同时随机抽取128例同期住院的新生儿肺炎、新生儿黄疸患儿作对照,应用logistic多元逐步回归分析的方法筛选HIE发病的危险因素。结果:两组患儿中10个围产因素存在统计学差异。应用logistic多元逐步回归分析结果显示:分娩方式、羊水污染、胎膜早破、脐带异常、Apgar评分异常等为主要危险因素。结论:增强孕妇医学保健意识、加强围产期保健、提高基层医疗机构产科质量、根据不同产妇和胎儿的具体情况,采取适当的个体化干预措施,对预防和减少新生儿HIE发生,降低围产儿死亡率和致残率具有重要意义。更多还原

【Abstract】 Objective To investigate the correlation between perinatal factors and the neonatal hypoxic-ischemic encephalopathy.Methods A total of 302 neonates diagnosed as hypoxic-ischemic encephalopath,with control of 128 cases having no HIE between 1992-2012 were retrospectively analyzed.The risk factors were scaled by stepwise regression analysis.Results There was a significant difference of perinatal factors in two groups.With stepwise regression analysis,HIE was significantly associated with the mode of deliver,meconium-stained amniotic fluid,premature rupture of membranes,umbilical cord abnormalities and Apgar scores.Conclusion Taking regular antenatal care,improving the quality of obstetrics and administrating intervention events individually are important factors which can lower the incidence rate and the mortality rate of HIE.更多还原