【摘要】 目的:探讨慢性乙型肝炎(以下简称慢性乙肝)患者血清的肝纤维化程度与血清透明质酸(HA)、层粘连蛋白(LN)、IV型胶原(IV C)及Ⅲ型前胶原氨端肽(PⅢNP)含量的关系。方法:用化学发光免疫分析法检测410例慢性乙肝患者血清HA、LN、IV C及PⅢNP的含量,同时结合临床特点,运用统计学方法对上述血清学指标的诊断价值进行分析。结果:慢性乙肝轻、中、重度及肝硬化患者血清HA、LN、IV C及PⅢNP水平均不同程度高于正常对照组(P<0.05或P<0.01)。结论:上述四项肝纤维化血清学指标的检测能在一定程度上反映肝纤维化的进展情况,对慢性乙肝患者肝纤维化的诊断有重要意义。更多还原

【Abstract】 Objective:To study the relationship between the 1evels of serum HA,LN,IV C,P III NP of chronic hepatitis and indexes of 1ive fibrosis.Methods:The levels of serum HA,LN,IVC and PⅢNP of chronic hepatitis of 410 cases were measured by Chemiluminescence immunoassay combined with c1inical characteristics.The diagnostic significance of the indexes of serum was analyzed with statistics.Results: The Value of HA、LN、IVC and PⅢNP in the chronic hepatitis group was Significantly higher than that in the normal comparative group(P<0.05 or P<0.01).Conclusions: The 1evels of serum HA,LN,IV C and PⅢNP are in concert with the degree of 1iver fibrosis,and these indexes are valuable for chronic hepatitis diagnoses combined with the clinics.更多还原