【摘要】 目的:探讨IL-23与儿童支气管哮喘的相关性。方法:应用双抗体夹心ELISA法分别检测正常对照组、哮喘组、激素治疗组儿童血清中IL-23水平。结果:哮喘组血清IL-23水平中位数13.7μg/L,明显高于正常对照组1.4μg/L,两者比较差异有显著性;应用吸入性糖皮质激素干预后的哮喘儿童血清IL-23水平为6.5μg/L,较激素干预前(15.2μg/L)明显降低,两者比较差异有显著性。结论:IL-23在支气管哮喘发病中可能发挥促炎作用。更多还原

【Abstract】 Objective:To study the relationship between interleukin 23(IL-23) and children asthma.Methods:The levels of sera IL-23 in normal control group,asthma group and glucocorticosteroid treatment group were detected by Double-Antibody Sandwich ELISA.Results:The median levels of IL-23 in asthma group(13.7 μg/L) was significantly higher than that in normal control group(1.4 μg/L) and it was statistically significant.After glucocorticosteroid treatment,the median levels of IL-23(6.5 μg/L) was significantly lower than before glucocorticosteroid treatment(15.2 μg/L) and it was statistically significant.Conclusion:IL-23 may play a role in asthma pathogenesis.更多还原