【摘要】 目的从细胞因子水平探讨幽门螺杆菌(HP)对慢性活动性胃炎发生发展的作用及其临床意义。方法收集91例慢性活动性胃炎患者,其中轻-中度慢性活动性胃炎患者51例,重度慢性活动性胃炎患者40例和健康对照者40例,采用ELISA法检测以上三组患者外周血中IL-6、TGF-β1及IL-17的浓度,并分析其与HP感染的关系。结果慢性活动性胃炎轻-中度组IL-6的浓度与对照组无统计学差异;TGF-β1、IL-17的浓度显著高于对照组(P<0.01)。重度组三种细胞因子的浓度均显著高于轻-中度组和对照组(P<0.01)。HP阳性患者IL-6、TGF-β1、IL-17的浓度均高于阴性患者(P<0.01)。结论细胞因子IL-6、TGF-β1及IL-17参与慢性活动性胃炎的发生发展;HP感染对炎症的发生发展有促进作用,通过检测上述细胞因子为临床评价治疗效果、判断预后以及进行免疫治疗提供一定的理论依据。更多还原

【Abstract】 Objective From the level of cytokines,analyze the affection of helicobacter pylori in chronic active gastritis development and its clinical significance.Methods 91 cases of chronic active gastritis patients(51 patients with mild-moderate chronic active gastritis,40 patients with severe chronic active gastritis,and 40 healthy controls)were detected by ELISA with peripheral blood IL-6,TGF-β1 and IL-17 concentrations,and analyzed its relationship with helicobacter pylori infection.Results Compared with the control group,IL-6 concentration of mild-moderate group showed no significant difference.The TGF-β1 and IL-17 concentration of mild-moderate group was significantly higher than the control group(P<0.01).The concentration of three cytokines in severe group were significantly higher than the mild-moderate group and the control group(P<0.01).The IL-6,TGF-β1 and IL-17 concentration in the positive group of helicobacter pylori infection patients were significantly higher than negative group(P<0.01).Conclusions Cytokines IL-6,TGF-β1 and IL-17 participate in the incidence of chronic active gastritis development.Helicobacter pylori infection could promote the development of inflammation.By detecting these cytokines can provide a theoretical basis for clinical evaluation of treatment,prognosis,and immunotherapy.更多还原