【摘要】 目的研究高迁移率蛋白A2(HMGA2)在垂体腺瘤中的表达及其与垂体腺瘤侵袭性的相关性。方法采用免疫组织化学法及RT-PCR法检测55例垂体腺瘤组织中HMGA2蛋白的表达。依据Wilson改良Hardy分类系统分级分期标准分组:侵袭性垂体腺瘤组18例,非侵袭性垂体腺瘤组37例。依据内分泌学检查分为:无功能性垂体腺瘤5例,功能性垂体腺瘤50例。结果 HMGA2在无功能垂体腺瘤中无表达,在功能性垂体腺瘤中表达率82%,差异有统计学意义。在侵袭性组表达阳性率32.43%,与侵袭性垂体腺瘤(100%)相比,差异有统计学意义。侵袭组HMGA2mRNA的表达水平较非侵袭组表达水平显著增高(0.891±0.172vs.0.372±0.181),功能性垂体瘤较非功能性垂体瘤HMGA2mRNA的表达水平显著增高(0.564±0.196vs.0),差异有统计学意义。结论 HMGA2的高表达在功能性垂体瘤的发生及垂体瘤的侵袭性中发挥重要的作用。更多还原

【Abstract】 Objective To study the relationship of the expressions of HMGA2 in pituitary adenomas and the relationships of the HMGA2 expressions with the invasiveness of pituitary adenomas was analyzed respectively.Methods The expressions of HMGA2 was determined by immunohistochemical technique and RT-PCR in 55 samples of pituitary adenomas.Results HMGA2 expressed in functional pituitary adenomas but not expressed in non-functional pituitary adenomas,expression in the invasive group was significantly higher than that of non-invasive group.Conclusions The high expression of HMGA2 plays an important role in the occurrence of functional pituitary adenomas and invasive in pituitary adenomas.更多还原