节点文献
伊曲康唑三唑酮侧链的合成工艺改进
Synthetic process improvement of triazones of the key intermediate of itraconazole
【摘要】 探索化合物4-[4-[4-(羟基苯基)-1-哌嗪基]苯基]-2,4-二氢-2-(1-甲基丙基)-3H-1,2,4-三唑-酮(A)的简便易行的合成方法。在不影响反应收率的前提下,找到了新的试剂代替文献中所用的价格昂贵或者毒性较大的试剂,既节约试剂成本又简化操作程序,制得化合物A。
【Abstract】 To find out an easier way to synthesis 4-[4-[4-(Hydroxybenzyl)-piperazinyl]benzyl]-2,4-dihydro-2-(1-methyl propyl)-3hydro-1,2,4-triazone(A).Substitute reagents were used and the target compound A were got without affecting the compound yied,the cost decreased and the processes were simplified.
- 【文献出处】 中国抗生素杂志 ,Chinese Journal of Antibiotics , 编辑部邮箱 ,2012年03期
- 【分类号】TQ463.5
- 【被引频次】2
- 【下载频次】234