【摘要】 目的研究莫诺苷对二磷酸腺苷(ADP)诱导兔血小板聚集后环氧酶(Cox)含量的影响。方法利用酶联免疫吸附剂测定法(ELISA)检测不同给药组间ADP诱导体外分离的兔血小板聚集后Cox的含量。结果与空白对照组相比,莫诺苷各剂量组均能显著降低ADP诱导兔血小板聚集后Cox的含量(P<0.001),并具有较好的浓度依赖性,其中高剂量组抑制率达30%左右。结论莫诺苷可能通过影响Cox的含量抑制ADP诱导的兔血小板聚集。更多还原

【Abstract】 Objective To investigate the effect of morroniside on cycloxygenase(Cox) in the condition of platelet aggregation induced by adenosine diphosphate(ADP) in rabbits.Methods The levels of Cox induced by ADP in different groups were detected by enzyme-linked immunosorbent assay(ELISA).Results Compared with the control group,all the morroniside groups significantly inhibited the increase of Cox induced by ADP(P<0.001),which had concentration dependence,and the inhibition rate of high dose group was 30%.Conclusion Morroniside can decrease the level of Cox and it may be the mechanism of morroniside on inhibiting the platelet aggregation induced by ADP in rabbits.更多还原