【摘要】 小胶质细胞是中枢神经系统中的免疫细胞,是中枢神经系统抵抗病原体入侵的第一道防线。当病原微生物进入脑组织后,小胶质细胞迅速做出反应,识别、吞噬病原微生物,呈递抗原和分泌多种生物活性物质。但是,小胶质细胞的过度活化又可诱发中枢神经系统免疫病理损伤或神经退行性病变。因而,具有生理和病理双重作用。本文就小胶质细胞在病毒感染性中枢神经系统疾病中的作用及其机制进行综述。更多还原

【Abstract】 Microglia,a class of resident cells in the brain,function as immune cells in the central nervous system(CNS),and they participate in the first line of defense against invading pathogens.When microorganisms enter the parenchyma of the brain,microglia will rapidly respond to the invasion.They are capable of recognizing and phagocytizing infectious pathogens,presenting antigens,and secreting bioactive substances.However,the excessive activation of microglia can lead to immune-mediated disorders and neurodegenerative diseases.Therefore,they play a role in both physiological and pathological conditions.This article reviews the functions and mechanisms of microglia in viral infections of the CNS.更多还原