【摘要】 目的分析婴幼儿在急性细菌性肠道感染及病毒性肠道感染时,超敏C-反应蛋白(CRP)数值与其疾病的相关性,为临床更有效地选择治疗药物提供科学依据。方法利用快速CRP分析仪,采用高敏感化学微粒增强浊度法对1512例儿科门诊肠道感染患儿进行检测。结果经诊断其中244例为急性细菌感染性肠炎,128例为轮状病毒感染性肠炎,1140例为非感染性肠道疾病;244例细菌感染性肠炎患儿中,CRP含量升高183例,检出率为75.0%,其中CRP为21～50mg/L有67例,CRP>50mg/L有24例;128例轮状病毒性肠炎患儿中,CRP含量升高12例占9.3%,其中CRP>20mg/L有2例;1140例非感染性肠道疾病患儿中CRP含量升高27例占2.4%,其中CRP>20mg/L只有1例;244例患细菌性肠道感染的患儿中,白细胞(WBC)升高>10.0×109/L有158例,占64.8%,其中CRP和WBC同时升高的有115例占47.1%,CRP升高而WBC正常的61例占25.0%。结论当婴幼儿发生急性肠道感染时,超敏CRP检测更有助于肠道感染性疾病各种类型的早期鉴别诊断,肠道细菌性感染时的CRP含量比肠道病毒性感染时的CRP含量有着明显的升高;超敏CRP检测较白细胞测定更迅速、更敏感;超敏CRP检测在对婴幼儿肠道感染性疾病的诊治中具有重要指导意义。更多还原

【Abstract】 OBJECTIVE To analyze the correlation between hs-CRP values and the diseases caused by acute bacterial intestinal infections and enterovirus infections so as to provide asientifil basis for reasonable use of antibiotics.METHODS Quickread CRP was applied to detect 1512 intestinal infectious pediatric patients who had pediatric patients with intestinal infections and made routine stool tests before.RESULTS Totally 244 cases were diagnosed as acute bacterial infectious enteritis,128 cases as rotavirus enteritis and 1140 cases as non-infective intestinal diseases.In the 244 patients with acute bacterial infectious enteritis,183 cases(75.0%) were found with increased CRP.There were 67 cases with CRP> 20 mg/L and 24 cases with CRP> 50 mg/L;in the 128 patients with rotaviral enteritis,12 cases(9.3%) were found with increased CRP.There were 2 cases with CRP > 20 mg/L;in the 1140 patients with non-infective intestinal diseases,27 cases(2.4%) were found with increased CRP.There was only one case with CRP > 20 mg/L;of 244 cases with bacterial intestinal infections,there were 158(64.8%) cases with the increase of WBC by more than 10.0×109/L,there were 115(47.1%) cases with the CRP and WBC increasing at the same time,and there were 61(25.0%) cases with the increase of CRP and normal WBC.CONCLUSION Hs-CRP detection can help to identify and diagnose various types of intestinal infections for infants with acute intestinal infections in the early stage.The CRP of the patients with bacterial intestinal infections increases more significantly than does the patients with enterovirus infections;in comparison with white blood cell detection,hs-CRP detection is more efficient and more sensitive;hs-CRP has great significance in the diagnosis and treatment of intestinal infectious diseases..更多还原