【摘要】 目的探讨解脲脲支原体(Uu)和人支原体(Mh)在泌尿生殖系统中的感染及耐药性,为临床提供新的流行病学资料及用药指导。方法对2978例泌尿生殖系统感染患者进行支原体属培养和抗菌药物的敏感试验。结果2978例患者中支原体阳性1101例,感染率为37.0%,其中单Uu阳性997例占33.5%,单Mh阳性31例占1.0%,Uu与Mh同时阳性73例占2.5%,女性感染率显著高于男性;Uu对多西环素、米诺环素、克拉霉素最敏感,Mh对多西环素、米诺环素、交沙霉素最敏感,Uu与Mh混合感染的耐药率明显高于单一Uu或Mh感染。结论支原体属引起泌尿生殖系统感染严重,主要由Uu感染引起,经验用药宜首选四环素类药物,鉴于支原体属的耐药状况严重,最好先做药敏试验,根据药敏结果合理用药以提高疗效,减少耐药菌株产生。更多还原

【Abstract】 OBJECTIVE To explore drug resistance of Ureaplasma urealyticum(Uu) and Mycoplasma hominis(Mh) causing urogenital tract infections so as to provide the data of epidemiology and offer reasonable application of antibiotics.METHODS The Mycoplasma culture was carried out with the samples of 2978 cases and then the drug susceptibility testing was performed.RESULTS There were 1101 patients who were infected with Mycoplasma in 2978 cases with the infection rate of 37.0%,including 997(33.5%) patients with Uu infection,31(1.0%)patients with Mh infections and 73(2.5%) patients with mixed Uu and Mh infection;the infection rate of female was remarkably higher than that of male;the top three sensitive antibiotics to Uu were doxycycline,mincycline,clarithromycin,while doxycycline,mincycline,and josamycin to Mh;the incidence of the mixed Un and Mh infections was significantly higher than that of single Uu or Mh infection.CONCLUSION Mycoplasma can lead severe urogenital tract infections which is mainly caused by Uu,and tetracyclines maybe the first choice of empirical drug;as the drug resistance of Mycoplasma is serious,it is necessary to perform the drug susceptibility testing and reasonably use antibiotics on the result so as to reduce the drug resistant strains.更多还原