【摘要】 目的:对大鼠灌胃川芎提取物后的吸收入脑成分进行分析鉴定。方法:采用UPLC-Q-TOF-MS对给药脑组织和空白脑组织进行分析,分析总离子流图寻找差异峰,然后根据保留时间、精确分子量、一级和二级质谱数据等鉴定差异峰。结果:川芎提取物给药后,发现3个化合物能透过血脑屏障进入脑组织,经鉴定为洋川芎内酯I,A和藁本内酯。结论:本研究将有助于川芎药效物质基础的阐明。更多还原

【Abstract】 Objective: To analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts.Method: The dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS.Different peaks were observed in total ion chromatograms and then identified according to their retention time,accurate mass weight,MS and MS/MS data.Result: After oral administration of Chuanxiong Rhizoma extracts,3 compounds were absorbed into rat brain tissues through BBB.They were identified as senkyunolide I,senkyunolide A and ligustilide.Conclusion: The study is helpful for interpreting effective substance of Ligusticum chuanxiong.更多还原