节点文献

唑来膦酸治疗35例原发性骨质疏松症的疗效及观察

Efficacy of zoledronic acid for the treatment of 35 primary osteoporosis patients

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 甄东邱冰

【Author】 ZHEN Dong,QIU Bing.Department of Orthopedics,People’s Hospital of Guizhou Province,Guiyang 550001,China

【机构】 贵州省人民医院骨科

【摘要】 目的观察唑来膦酸治疗原发性骨质疏松症的临床疗效及安全性。方法应用唑来膦酸注射液治疗35例57~85岁原发性骨质疏松症患者,分别观察治疗前后患者骨痛的缓解情况、血钙、磷、碱性磷酸酶、骨钙素、尿DPD/Cr变化情况。采用双能X线骨密度仪测定患者治疗前后骨密度。观察患者治疗后不良反应的发生情况。结果全部患者骨痛症状明显改善,总优良率达100%。血钙、磷、碱性磷酸酶、骨钙素无显著变化,尿DPD/Cr较治疗前显著降低(P<0.01)。骨密度较治疗前显著增加(P<0.01),35例患者均无明显不良反应发生。结论唑来膦酸是治疗原发性骨质疏松症的安全有效性药物。

【Abstract】 Objective To observe the efficacy and safety of zoledronic acid for the treatment of primary osteoporosis.Methods Thirty-five primary osteoporosis patients aged from 57 to 85 years old were treated with 5mg zoledronic acid.The mitigation of pains and the variation of serum calcium,phosphate,alkaline phosphatase,and urine DPD/Cr were observed before and after the treatment.BMD was measured using dual energy X-ray absorptionmetry(DXA).The incidence of adverse reactions after the treatment was observed.Results Pain was significantly ameliorated in all patients and the total excellent and good rate was 100%.The result of serum calcium,phosphorus,alkaline phosphatase,and BGP showed no significant change.The result of urinary DPD/Cr after the treatment was significantly lower than that before the treatment(P<0.01).BMD was significantly lower than that before the treatment(P<0.01).No obvious adverse reactions happened in all 35 patients.Conclusion Zoledronic acid is an effective and safe drug for the treatment of primary osteoporosis.

  • 【文献出处】 中国骨质疏松杂志 ,Chinese Journal of Osteoporosis , 编辑部邮箱 ,2012年02期
  • 【分类号】R580
  • 【被引频次】29
  • 【下载频次】221
节点文献中: 

本文链接的文献网络图示:

本文的引文网络