【摘要】 癌痛影响着每一位晚期癌症患者的正常生活。阿片类药物是目前治疗癌痛的主力军,但是随着治疗和研究的深入,阿片类药物诱发的痛觉过敏(OIH)等并发症也逐渐凸显并越发受到重视,相关机制的研究正成为癌痛治疗领域的热点。本文从中枢谷氨酰能系统、信号传导通路、阿片受体及外周受体、细胞内机制、遗传因素及相关临床研究等方面对OIH的研究进展进行综述,旨在为临床上OIH的诊断及治疗提供相关依据。更多还原

【Abstract】 All patients with advanced cancer suffer from cancer pain.Currently,opioids are the first line drugs in the management of cancer pain.Consequently,the incidence of opioid-induced hyperalgesia(OIH ) is increasing and more attention has been focused on it.Research on the related mechanisms of OIH has recently becomes a hot topic in cancer pain control.The research progress on OIH from the central glutaminergic system,signal transduction pathways,opioid and peripheral receptors,the intracellular mechanism, genetic factors,and relevant clinical observations are discussed to provide information for clinical diagnosis and treatment of OIH.更多还原