【摘要】 目的:研制TJ0711盐酸盐混合骨架缓释片,并评价其体外释放特性。方法:研究了HPMC的黏度和用量,十八醇、CMC-Na的用量对药物释放的影响,并通过正交试验设计对片剂的处方进行优化。结果:正交设计所得最优处方为十八醇、HPMC K4M、CMC-Na的用量分别为片重的20%,40%,10%。药物体外释放良好,符合Higuchi模型(Q=33.909t1/2-20.263,r=0.996 2),持续释药达12 h。结论:经正交优化的TJ0711盐酸盐缓释片处方可行。更多还原

【Abstract】 OBJECTIVE To prepare sustained-release TJ0711 hydrochloride tablets with several kinds of matrix materials and evaluate its release property in vitro.METHODS The effects of the viscosity of HPMC,amount of HPMC,stearyl alcohol,CMC-Na were studied,using release rate of drug as marker.The formulation was optimized by the orthogonal design test.RESULTS The optimized prescription: amount of HPMC K4M,stearyl alcohol and CMC-Na were 40%,20%,10%,respectively.The release rate of this drug conformed to Higuchi equation(Q=33.909t1/2-20.263,r=0.996 2) and the drug was sustained released in vitro within 12 h.CONCLUSION The formulation of TJ0711 hydrochloride sustained-release tablets is feasible.更多还原