【摘要】 目的探讨骨髓MICM分型在EBV+NK/T细胞淋巴增生性疾病的临床意义探讨。方法收集5例曾于外院诊断为EBV相关噬血细胞综合征、慢性活动性EBV感染的病例,回顾患儿的临床资料、实验室、血清学及骨髓MICM分型及随访结果,修正诊断为恶性淋巴瘤(白血病)及EBV+NK/T细胞淋巴增生性疾病。对应用MICM分型在EBV+NK/T细胞淋巴增生性疾病的诊断中的应用做初步总结。结果 5例中有3例明确诊断为淋巴造血系统恶性疾病,而不是停留在噬血细胞综合征的诊断。结论 EBV检测及MICM分型有助于EBV+NK/T细胞淋巴增生性疾病的诊断。对于EBV感染淋巴增生性疾病,骨髓MICM分型具有很重要的诊断意义。更多还原

【Abstract】 Objective To discuss the meaning of MICM of bone marrow for the diagnosis of the EBV + NK/T Lymphoproliferative disease in childhood.Methods To report 5 cases of EBV + NK/T Lymphoproliferative disease,to introduce the MICM of the 5 cases,and express the important role of MICM in such cases.Especially when the EBVDNA is positive,the HLH or CAEBV is not always the right diagnosis.Results 3 cases of 5 were diagnosed as the tumors of hematopoietic and lymphoid tissues in stead of hemophagocytic syndrome by doing bone marrow MICM classification.Conclusions EBV-associated Lymphoproliferative diseases is a cluster of disease with poor prognosis. Using MICM classification of bone marrow can help doctor to make right diagnosis.更多还原