【摘要】 目的研究食管胸中段癌术后静脉自控镇痛(PCIA)时应用喷他佐辛的镇痛效果和不良反应,并与芬太尼作比较。方法选择本院2011年6月～2012年5月行食管胸中段癌根治术的患者60例,ASAⅠ～Ⅱ,NYHAⅠ～Ⅱ级,随机分为两组:喷他佐辛组(P组),配喷他佐辛3mg/kg;芬太尼组(F组),配芬太尼10μg/mL。两组术后镇痛均应用一次性电子静脉自控输注泵,采用LCP模式:负荷量5mL+持续量2mL+单次按压注入量0.5mL,锁定时间15min,容量为100mL。观察患者术后4、8、24h的疼痛、镇静评分,镇痛效果总体评价及不良反应。结果两组镇痛、镇静效果差异无统计学意义(P>0.05);P组发生恶心呕吐1例(3.3%),F组发生6例(20%),差异有统计学意义(P<0.05);P组发生皮肤轻度瘙痒0例,F组发生5例(16.7%),差异有统计学意义(P<0.05)。P组不良反应发生率为3.3%,F组为43.4%,两组间比较差异有统计学意义(P<0.01)。结论 PCIA应用喷他佐辛与芬太尼均能达到良好的镇痛效果,但喷他佐辛的不良反应发生率较低。更多还原

【Abstract】 Objective To study the analgesic effects and adverse reactions of pentazocine in the patient controlled intravenous analgesia after chest esophageal cancer surgery,and compare with fentanyl.Methods Sixty patients(ASAⅠ～Ⅱ,NYHAⅠ～Ⅱ) undergoing radical resection of esophageal chest paragraph cancer were randomly divided into two groups:pentazocine group(P group),pentazocine 3 mg/kg;fentanyl group(F group),fentanyl 10 μg/kg.Controlled application of disposable electronic intravenous pump was used in postoperative analgesia with LCP mode:load capacity was 5 mL,continuous injection was 2 mL,continuous injection volumes of single compression was 0.5 mL,lockout time was 15 min,with a capacity of 100 mL.Analgesia and sedation score,the overall evaluation of analgesic effect and adverse reactions of two groups on 4,8 and 24 h were observed.Results There were no significant differences with analgesic and sedative effect between two groups(P > 0.05);Nausea and vomiting occoured in 1 case(3.3%) in P group,6 cases(20%) in F group,there were significant differences between two groups(P < 0.05);Mild skin itching occurred in 0 cases in P group,0 case in F group,5 patient(16.7%),there were significant differences between two groups(P < 0.05).Adverse reactions occurred in 1 case(3.3%) in P group,3 cases(43.4%) in F group,there were significant differences between two groups(P < 0.01).Conclusion PCIA applicating pentazocine and fentanyl has a good analgesic effect,but pentazocine has lower incidence of adverse reactions.更多还原