【摘要】 目的探讨不同血浆脑钠素N端前体肽(NT-proBNP)水平的急性心肌梗死(AMI)患者发病后1、3、6个月的左室重构差别,从而探讨NT-proBNP的临床应用价值。方法 NT-proBNP检测试剂盒检测116例AMI患者发病后24h血浆NT-proBNP水平,并心脏多普勒随访患者发病1、3、6个月左室收缩及舒张末期直径(LVDs/d),左心室射血分数(LVEF)。结果 (1)AMI患者发病后24h血浆NT-proBNP水平[(2965.68±456.32)pg/mL]明显高于对照组[(126.26±35.38)pg/mL],差异有统计学意义(P<0.05);(2)发病1个月AMI患者NT-proBNP重度升高组左室重构指标与前两组比较差异有统计学意义(P<0.05),前两组之间比较差异无统计学意义,P>0.05;发病3、6个月不同血浆NT-proBNP水平的AMI组两两比较差异有统计学意义(P<0.05)。结论血浆NT-proBNP可以预测AMI患者远期心室重构,特别是血浆NT-proBNP>5000pg/mLAMI患者早期即出现严重的心室重构。更多还原

【Abstract】 Objective To investigate left ventricular remodeling of different plasma N-terminal brain natriuretic peptide precursor peptide(NT-proBNP) levels in acute myocardial infarction(AMI) after onset,in one month,three months and six months,so as to explore the clinical application of NT-proBNP value.Methods Plasma NT-proBNP of the 116 patients with AMI were detected by NT-proBNP assay kit,24 hours after the onset.Left ventricular systolic and diastolic final diameter(LVDs/d),left ventricular ejection fraction(LVEF) were detected by echocardiographic after onset,in one month,three months and six months.Results(1) Plasma NT-proBNP level [(2 965.68 ± 456.32) pg/mL] of AMI patients 24 hours after the onset was significantly higher than the level [(126.26 ± 35.38) pg/mL] of control group,the difference was significant(P < 0.05);(2) The difference of left ventricular remodeling index,between the first two groups of patients with AMI NT-proBNP and severe elevated group after onset,in one month the difference was statistical significance(P < 0.05),however between the first two groups was not statistically significant(P > 0.05);the difference of left ventricular remodeling index,among different plasma NT-proBNP levels groups was significant after onset,in three months and six months(P < 0.05).Conclusion Plasma NT-proBNP can predict long-term ventricular remodeling in patients with AMI,especially severe ventricular remodeling will happen earlier in NT-proBNP severe elevated AMI patients(> 5 000 pg/mL).更多还原