汕头成人下呼吸道感染流感嗜血杆菌的耐药性分析

【摘要】 目的:探讨汕头地区成人下呼吸道感染流感嗜血杆菌(Hi)的耐药现状,为临床治疗提供参考依据。方法:收集成人下呼吸道感染患者中分离的流感嗜血杆菌,集中后经VITEK-2compact系统和Ⅴ+Ⅹ、Ⅴ、Ⅹ因子试验作复检,K-B法测定其药敏结果,以Nitrocefin试剂做β-内酰胺酶测定。结果:144株流感嗜血杆菌中耐药率以氨苄西林、复方新诺明和四环素较高,分别为53.5%、60.4%和20.8%。对阿莫西林/棒酸、头孢呋辛、三代头孢、环丙沙星、左氧氟沙星、和氯霉素耐药率较低2.8%～14.6%,未出现亚胺培南、阿奇霉素耐药株。产β-内酰胺酶62株,产酶率43.1%。结论:本地区流感嗜血杆菌对氨苄西林的耐药率较高,氨苄西林和复方新诺明已不适于本地区成人流感嗜血杆菌感染的经验治疗,临床上应根据本地区耐药监测数据合理选用抗菌药物。更多还原

【Abstract】 Objective:To discuss the drug resistance status of haemophilus influenzae of adult with lower respiratory tract infection in ShanTou,and to provide reference basis for clinical treatment.Methods:The haemophilus influenzae isolates were collected from 3 hospitals in ShanTou.The strain identification confirmation by VITEK-2compact and and factor Ⅴ + Ⅹ、Ⅴ、Ⅹ test,antimicrobial susceptibility detected by K-B method,beta-lactamase was detected with Nitrocefin reagent.Results:About 53.5%,60.4% and 20.8% of the 144 haemophilus influenzae strains were resistant to ampicillin,cotrimoxazole and tetracycline,respectively.The 2.8% ～ 14.6% of these strains were resistant to amoxicillin/clavulanic acid,cefuroxime,ceftriaxone,ciprofloxacin,levofloxacin,d and chloromycetin.No strains was resistant to imipenem and azithromycin.62 strains produced beta-lactamase,enzyme production rate was 43.1%.Conclusion:Theresistant rate to ampicillin and prevalenceof beta-lactamase of haemophilus influenzae of adult in ShanTou was much higher than in other regions.Ampicillin and cotrimoxazole already were not suitable for experience treatment of haemophilus influenzae infection.更多还原