【摘要】 为了研究氟苯尼考双混悬型乳剂的临床治疗效果,确定该新制剂的治疗剂量及使用间隔时间,建立体重为12±1.5kg的大约克小肥猪沙门氏菌人工感染病理模型,以氟苯尼考注射液为对照组,肌肉注射氟苯尼考双混悬型乳剂高(30mg/kg·bw)、中(20mg/kg·bw)和低(10mg/kg·bw)剂量组开展临床治疗与观察。结果所有试验组治疗率均在70%以上,高剂量组显著高于低剂量组和药物对照组(p<0.05),中剂量组显著高于药物对照组(p<0.05)。因此,氟苯尼考双混悬型乳剂中剂量组(20mg/kg·bw)3d给药1次,连续2次可以达到良好的治疗效果。更多还原

【Abstract】 In order to explore the clinical therapeutic effect of Dual Suspension Emulsion of Florfenicol(DSEF) and determine the medication regimen, The swine Salmonella artificial infection model of Yorkshire castrated pigs of 12±1.5kg body weight was established. The Florfenicol Injection(FI) was used as the control group and the high ( 30mg / kg·bw ), ( 20mg / kg·bw ) and low dose ( 10mg / kg·bw ) group of DSEF were used for clinical treatment and observation.The results show that the treatment rates of all the test group were 70% above ; high dose group was higher than that in low dose group and drug control group (P < 0.05) and middle dose group was higher than that in drug control group (P < 0.05). Therefore, the medication regimen of DSEF for middle dose group (20mg/kg·bw) 3d/times and 2 times in a row was a good treatment.更多还原