【摘要】 目的研究慢性肾功能衰竭(chronic renal failure,CRF)患者颈动脉斑块情况与相关危险因素的关系。方法对43例CRF患者采用高分辨率高频彩超观察双侧颈动脉内-中膜厚度(IMT)及斑块情况,同时抽血检测血钙、磷,胆固醇、甘油三酯、二氧化碳结合力、血肌酐,并计算钙磷乘积。结果 43例CRF患者,24例(55.8%)存在颈动脉斑块。斑块组IMT值、血磷及钙磷乘积较无斑块组显著增高(分别P<0.01、P<0.05、P<0.05)。结论 CRF患者颈动脉斑块的超声特征表现为高回声的钙化斑块,且多位于动脉中膜,CRF患者颈动脉钙化斑块的形成与钙磷代谢紊乱密切相关,因此可将颈动脉有无斑块作为一个筛选因素来预测CRF患者的心血管疾病病变程度。更多还原

【Abstract】 Objective To investigate the relationship between carotid artery plaque and calcium phosphorus metabolism disorder in patients with chronic renal failure（CRF）.Methods The intima-media thickness（IMT） and plaque of bilateral carotid artery were detected by ultrasonography in 43 patients with CRF and serum calcium/phosphorus, serum lipid profile,creatinine,CO₂CP were checked at the same time.Results Carotid plaque was confirmed in 24 of 43 cases with CRF（55.8%）.IMT,serum phosphorus and calcium-phosphorus product were significantly higher（P< 0.01,P<0.05,P<0.05 respectively） in patients with carotid plaque than those in patients without carotid plaque. Conclusions Carotid plaque was very prevalent in CRF patients.IMT,serum phosphorus and calcium phosphorus product were closely correlated with carotid plaque in such patients.Carotid plaque of CRF patients is mostly hyperechoic plaques,and many in the media layer.It is very important to reduce the incidence and mortality of cardiovascular disease of CRF patients with the early detection of carotid artery plaque by high-resolution color Doppler ultrasound.更多还原