【摘要】 背景与目的:卵巢癌患者因肿瘤负荷、手术创伤等原因,凝血系统的平衡状态常被打破,容易出现出血或血栓性疾病。本研究旨在探讨血浆D-二聚体在卵巢癌患者手术前、后监测中的应用价值。方法:测定161例卵巢癌患者和41例卵巢良性肿瘤患者血浆D-二聚体水平,对其中23例卵巢癌患者术后D-二聚体变化进行随访监测。结果:卵巢癌组血浆D-二聚体水平明显高于良性肿瘤组(P<0.01);卵巢癌患者血浆D-二聚体水平随分期增加而明显升高,差异有统计学意义(χ2=78.894,P<0.01),提示卵巢癌患者凝血及纤溶功能障碍随病情发展呈现加重趋势;9例患者术后出现血栓性疾病前,其D-二聚体水平均呈持续高水平或一过性下降后突然升高。结论:监测卵巢癌患者手术前后血浆中D-二聚体浓度,有助于术前筛查血栓高风险人群,预警术后深静脉血栓形成,争取早预防、早诊断、早治疗,改善患者的预后。更多还原

【Abstract】 Background and purpose:Bleeding or thrombotic diseases are easily to be found in ovarian cancer patients,because the balance of their coagulation system are being undermined due to tumor burden or surgery.We studied the value of plasma D-dimer monitoring before and after ovarian cancer surgery.Methods:The plasma concentration of D-dimer levels were measured in 161 ovarian cancer patients and 41 benign ovarian tumor patients,and then we followed up to analyze the change of D-dimer concentration of 23 postoperative patients.Results: The plasma levels of D-dimer in ovarian cancer patients were found to be significantly higher than those in ovarian benign tumor(P<0.01).Significantly differences of D-dimer levels were found among different ovarian cancer stages(χ2=78.894,P<0.01),which suggested that ovarian cancer patients’ coagulation and fibrinolysis dysfunction become more serious during the progression of disease.The D-dimer amount kept at a high level or raised suddenly after a transient decrease in 9 patients who were seized with thrombotic diseases after operation.Conclusion:Monitoring the plasma D-dimer level before and after ovarian cancer operation could help finding out those who have high probability of thrombotic diseases and preventing deep venous thrombosis after operation.It also helps us to strive for early prevention,early diagnosis,early treatment,and to improve the prognosis of the patients.更多还原